Insulin treatment in type 1 diabetes mellitus

Insulin treatment in type 1 diabetes mellitus

AR Esteghamati, MD

Professor of Endocrinology and Metabolism

TUMS

• DCCT and other smaller studies demonstrated that improved glycemic control with intensive insulin therapy in T1 DM led to graded reductions in
• Retinopathy
• Nephropathy
• Neuropathy
• Gain of 15.3 years of complication free living compared to conventional therapy
• Gain of 5.1 years of life compared to conventional therapy

EDIC study

• During combined mean 17 years of follow-up
• 46 CV events occurred in 31 patients randomized to intensive therapy in DCCT
• compared with 98 events in 52 patients randomized to conventional therapy.
• The EDIC demonstrated that intensive insulin therapy also reduces cardiovascular morbidity and mortality